Proof of drug hypersensitivity using an in vivo leukocyte migration inhibition test

22 chloramphenicol allergics, 10 penicillin allergics and 6 patients with a chromate eczema as well as altogether 34 non-allergic control persons with healthy skin were examined according to the skin chamber method. After addition of the adequate antigen (chloramphenicol, penicillin, ammonium bichro...

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Bibliographic Details
Published in:	Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete Vol. 32; no. 5; p. 123
Main Authors:	Ruffert, K, Wätzig, V
Format:	Journal Article
Language:	German
Published:	Germany 01-03-1977
Subjects:	Cell Migration Inhibition - methods Chloramphenicol - adverse effects Drug Hypersensitivity - diagnosis Drug Hypersensitivity - immunology Humans Leukocytes - immunology Penicillins - adverse effects
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Summary:	22 chloramphenicol allergics, 10 penicillin allergics and 6 patients with a chromate eczema as well as altogether 34 non-allergic control persons with healthy skin were examined according to the skin chamber method. After addition of the adequate antigen (chloramphenicol, penicillin, ammonium bichromate) into one of the two simultaneously applied skin chambers in sensitized persons an inhibition of the leucocyte migration in the antigen chamber develops. The polymorphonuclear neutrophilic granulocytes mobilised into the inflammation field were regarded as indicator cells. 5 chloramphenicol allergics with eczematous skin abnormalities and all control persons were negative. The investigation method is simply to be performed and therefore it is particularly suitable for clinical routine work.
ISSN:	0044-2542