Detection of 3 beta-hydroxy-5-cholenoic acid in human amniotic fluid

Studies of the bile acids of human meconium suggest that a fetal pathway of bile acid synthesis exists which leads to formation of 3beta-hydroxy-5-cholenoic acid, a bile acid not found in serum of healthy pregnant women. To obtain additional support for this hypothesis, cholic, chenodeoxycholic, and...

Full description

Saved in:

Bibliographic Details
Published in:	Schweizerische medizinische Wochenschrift Vol. 107; no. 15; p. 529
Main Authors:	Paumgartner, G, Délèze, G, Karlaganis, G, Giger, W, Reinhard, M, Sidiropoulos, D
Format:	Journal Article
Language:	German
Published:	Switzerland 16-04-1977
Subjects:	Adolescent Adult Amniotic Fluid - analysis Bile Acids and Salts - analysis Bile Acids and Salts - metabolism Female Fetus - metabolism Humans Liver - embryology Pregnancy
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Studies of the bile acids of human meconium suggest that a fetal pathway of bile acid synthesis exists which leads to formation of 3beta-hydroxy-5-cholenoic acid, a bile acid not found in serum of healthy pregnant women. To obtain additional support for this hypothesis, cholic, chenodeoxycholic, and 3beta-hydroxy-5-cholenoic acid were measured in amniotic fluid specimens from 18 pregnant women without liver disease. The finding of a considerable percentage of 3beta-hydroxy-5-cholenoic acid (mean: 34 molar %; range 3-71 molar % of total bile acids) in amniotic fluid strengthens the hypothesis that a fetal pathway of bile acid synthesis exists which begins with oxidation of the cholesterol side chain.
ISSN:	0036-7672