Effect of abdominal aortic clamping on the kallikrein-kinin system and the activity of lactate dehydrogenase and its isoenzymes during reconstructive operations

• Published in: Kardiologiia Vol. 18; no. 8; p. 78
• Main Authors: Seidov, V D, Agapova, E I, Pospelova, E P
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-08-1978
• Subjects: Aorta, Abdominal - physiology; Aorta, Abdominal - surgery; Aortic Diseases - surgery; Aprotinin - administration & dosage; Arteriosclerosis - surgery; Constriction; Enzyme Activation; Esterases - blood; Humans; Isoenzymes; Kallikreins - blood; Kinins - blood; L-Lactate Dehydrogenase - blood; Prekallikrein - blood; Time Factors
• ISSN: 0022-9040

To study the effect of abdominal aorta clamping and revascularization and appraise the efficacy of the drug gordox during surgical intervention, the values of the kinin system, acid-base balance, acid metabolites, and the total activity of lactic dehydrogenase and its isoenzymatic spectrum were determined in 24 patients with aortic stenosis of atherosclerotic origin. In patients who did not receive gordox, the kinin system became markedly activated after the clamp was removed from the aorta, which led to a sharp fall in arterial pressure, the development of metabolic acidosis, and activation of enzymes of the glycolytic cycle. Preventive administration of gordox in the other group of patients during operation inhibited the processes of activation of the kinin system, stabilized hemodynamics, improved tissue circulation and prevented the development of hypoxia.