CRP and neutrophils: functional effects and complex uptake

• Published in: Clinical and experimental immunology Vol. 63; no. 3; pp. 718 - 727
• Main Authors: SHEPHARD, E. G, ANDERSON, R, STRACHAN, A. F, KUHN, S. H, DE BEER, F. C
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01-03-1986
• Subjects: Adult; Biological and medical sciences; C-Reactive Protein - metabolism; C-Reactive Protein - pharmacology; Cell Movement - drug effects; Chemotaxis, Leukocyte - drug effects; Fundamental and applied biological sciences. Psychology; Humans; Inflammation; Lipoproteins, LDL - pharmacology; Luminescent Measurements; Molecular and cellular biology; Neutrophils - drug effects; Neutrophils - metabolism; Polysaccharides, Bacterial - blood; Trypsin - pharmacology; Human; Leukocyte; Polyoside; Complement; Inflammation; Clearance; Complexes; Streptococcus pneumoniae; Streptococcaceae; Anti C protein; Acute phase protein; Leucocyte function; Neutrophile; Bacteria; Β-Lipoprotein
• ISSN: 0009-9104; 1365-2249

The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of low density lipoprotein inhibited entry of complexed CPS into neutrophils but had no effect on entry of CRP alone. Pure human CRP was shown to have no effect on neutrophil chemotaxis and oxidative metabolism.