Effects of age and long-term endurance training on VO2 kinetics

• Published in: Medicine and science in sports and exercise Vol. 47; no. 2; pp. 289 - 298
• Main Authors: Grey, Tyler M, Spencer, Matthew D, Belfry, Glen R, Kowalchuk, John M, Paterson, Donald H, Murias, Juan M
• Format: Journal Article
• Language: English
• Published: United States 01-02-2015
• Subjects: Adaptation, Physiological; Adult; Aged; Aging - physiology; Heart Rate; Humans; Male; Middle Aged; Muscle, Skeletal - blood supply; Oxygen Consumption; Physical Education and Training; Physical Endurance - physiology; Pulmonary Gas Exchange; Spectroscopy, Near-Infrared; Time Factors; Young Adult
• ISSN: 1530-0315
• DOI: 10.1249/MSS.0000000000000398

This study examined the effects of age and training status on the pulmonary oxygen uptake (VO2p) kinetics of untrained and chronically trained young, middle-age, and older groups of men.
Breath-by-breath VO2p and near-infrared spectroscopy-derived muscle deoxygenation ([HHb]) were monitored continuously in young (20-39 yr) trained (YT, n = 8) and untrained (YuT, n = 8), middle-age (40-59 yr) trained (MT, n = 9) and untrained (MuT, n = 9), and older (60-85 yr) trained (OT, n = 9) and untrained (OuT, n = 8) men. On-transient VO2p and [HHb] responses to cycling exercise at 80% of the estimated lactate threshold (three repeats) were modeled as monoexponential. Data were scaled to a relative percentage of the response (0%-100%), the signals time aligned, and the individual [HHb]-to-VO2p ratio was calculated as the average [HHb]/VO2 during the 20- to 120-s period after exercise onset.
The time constant for the adjustment of phase II pulmonary VO2 (τVO2p) was larger in OuT (42.0 ± 11.3 s) compared with that in YT (17.0 ± 7.5 s), MT (18.1 ± 5.3 s), OT (19.8 ± 5.4 s), YuT (25.7 ± 6.6 s), and MuT (24.4 ± 7.4 s) (P < 0.05). Similarly, the [HHb]/VO2 ratio was larger than 1.0 in OuT (1.30 ± 0.13, P < 0.05) and this value was larger than that observed in YT (1.01 ± 0.07), MT (1.04 ± 0.05), OT (1.04 ± 0.04), YuT (1.05 ± 0.03), and MuT (1.02 ± 0.09) (P < 0.05).
This study showed that the slower VO2kinetics typically observed in older individuals can be prevented by long-term endurance training interventions. Although the role of O2 delivery relative to peripheral use cannot be elucidated from the current measures, the absence of age-related slowing of VO2 kinetics seems to be partly related to a preservation of the matching of O2 delivery to O2 utilization in chronically trained older individuals, as suggested by the reduction in the [HHb]/VO2 ratio.