Nuclear deoxyribonucleic acid heterogeneity of ovarian borderline malignant serous tumors

Sixteen borderline malignant serous ovarian tumors and seven well-differentiated invasive serous ovarian carcinomas were examined with the technique of Feulgen microspectrophotometry for the determination of nuclear deoxyribonucleic acid (DNA) ploidy patterns (diploid versus aneuploid) and ploidy le...

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Bibliographic Details
Published in:	Obstetrics and gynecology (New York. 1953) Vol. 67; no. 4; p. 478
Main Authors:	Fu, Y S, Ro, J, Reagan, J W, Hall, T L, Berek, J
Format:	Journal Article
Language:	English
Published:	United States 01-04-1986
Subjects:	Adult Aneuploidy Cystadenocarcinoma - analysis Cystadenocarcinoma - pathology Diploidy DNA, Neoplasm - analysis Female Humans Middle Aged Neoplasm Invasiveness Neoplasm Staging Ovarian Neoplasms - analysis Ovarian Neoplasms - pathology Prognosis Spectrophotometry
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Summary:	Sixteen borderline malignant serous ovarian tumors and seven well-differentiated invasive serous ovarian carcinomas were examined with the technique of Feulgen microspectrophotometry for the determination of nuclear deoxyribonucleic acid (DNA) ploidy patterns (diploid versus aneuploid) and ploidy levels of the stem cell lines. Of the nine stage I-II borderline malignant tumors, only one (11%) was aneuploid. In contrast, four of seven (57%) stage III borderline malignant neoplasms and all stage III carcinomas were aneuploid. The stem cell modal values in all borderline serous tumors were less than triploid (3N) while in five of seven carcinomas stem cell modal values were greater than triploidy. This contrast in ploidy patterns and ploidy levels may explain the differences in biologic behavior between borderline malignant serous tumors and invasive serous carcinomas of the ovary.
ISSN:	0029-7844