3-Aminothymidine inhibits growth of cultured human T-cell acute lymphoblastoid leukemia cells

N3-Aminated derivatives of thymidine, deoxyuridine and deoxycytidine were synthesized and their cell growth inhibition activity was tested using two cultured human cell lines, CCRF-HSB-2 and KB. Among the compounds tested, 3-aminothymidine showed growth inhibition activity against CCRF-HSB-2 cells a...

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Bibliographic Details
Published in:	Anticancer research Vol. 14; no. 5A; p. 2061
Main Authors:	Ashida, N, Asano, S, Kohda, K
Format:	Journal Article
Language:	English
Published:	Greece 01-09-1994
Subjects:	Cell Division - drug effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxyuridine - analogs & derivatives Deoxyuridine - pharmacology DNA, Neoplasm - biosynthesis Humans KB Cells Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - metabolism Neoplasm Proteins - biosynthesis RNA, Neoplasm - biosynthesis Thymidine - analogs & derivatives Thymidine - pharmacology Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects
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Summary:	N3-Aminated derivatives of thymidine, deoxyuridine and deoxycytidine were synthesized and their cell growth inhibition activity was tested using two cultured human cell lines, CCRF-HSB-2 and KB. Among the compounds tested, 3-aminothymidine showed growth inhibition activity against CCRF-HSB-2 cells and inhibited DNA synthesis in these cells.
ISSN:	0250-7005