Potentiation of growth hormone activity in sheep using monoclonal antibodies

Monoclonal antibody OA11 was raised against ovine GH; its effects on GH activity were examined in a target species relevant for animal production in vivo. The monoclonal antibody was found to enhance the galactopoietic response to exogenous GH in adult lactating ewes and also to potentiate the diabe...

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Bibliographic Details
Published in:	Journal of endocrinology Vol. 120; no. 2; p. R15
Main Authors:	Pell, J M, Johnsson, I D, Pullar, R A, Morrell, D J, Hart, I C, Holder, A T, Aston, R
Format:	Journal Article
Language:	English
Published:	England 01-02-1989
Subjects:	Animals Antibodies, Monoclonal - immunology Female Growth Hormone - immunology Growth Hormone - pharmacology Insulin Insulin-Like Growth Factor I - blood Lactation - drug effects Pregnancy Sheep - physiology
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Summary:	Monoclonal antibody OA11 was raised against ovine GH; its effects on GH activity were examined in a target species relevant for animal production in vivo. The monoclonal antibody was found to enhance the galactopoietic response to exogenous GH in adult lactating ewes and also to potentiate the diabetogenic activity of both exogenous and endogenous GH in ewe lambs. Thus it was shown that GH activity may be manipulated above its usual dose-response range in normal, intact animals of commercial importance via immunological means.
ISSN:	0022-0795
DOI:	10.1677/joe.0.120R015