Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study

• Published in: American journal of epidemiology Vol. 185; no. 8; pp. 697 - 711
• Main Authors: Farvid, Maryam S, Malekshah, Akbar F, Pourshams, Akram, Poustchi, Hossein, Sepanlou, Sadaf G, Sharafkhah, Maryam, Khoshnia, Masoud, Farvid, Mojtaba, Abnet, Christian C, Kamangar, Farin, Dawsey, Sanford M, Brennan, Paul, Pharoah, Paul D, Boffetta, Paolo, Willett, Walter C, Malekzadeh, Reza
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15-04-2017
• Subjects: Cardiovascular Diseases - mortality; Dairy Products - adverse effects; Diet Surveys; Female; Humans; Iran - epidemiology; Male; Middle Aged; Mortality; Neoplasms - mortality; Original Contributions; Proportional Hazards Models; Prospective Studies; cardiovascular disease; yogurt; milk; mortality; Golestan Cohort Study; cancer; dairy products; cheese
• ISSN: 0002-9262; 1476-6256
• DOI: 10.1093/aje/kww139

We investigated the association between dairy product consumption and all-cause, cardiovascular disease (CVD), and cancer mortality in the Golestan Cohort Study, a prospective cohort study launched in January 2004 in Golestan Province, northeastern Iran. A total of 42,403 men and women participated in the study and completed a diet questionnaire at enrollment. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. We documented 3,291 deaths (1,467 from CVD and 859 from cancer) during 11 years of follow-up (2004-2015). The highest quintile of total dairy product consumption (versus the lowest) was associated with 19% lower all-cause mortality risk (hazard ratio (HR) = 0.81, 95% confidence interval (CI): 0.72, 0.91; Ptrend = 0.006) and 28% lower CVD mortality risk (HR = 0.72, 95% CI: 0.60, 0.86; Ptrend = 0.005). High consumption of low-fat dairy food was associated with lower risk of all-cause (HR = 0.83, 95% CI: 0.73, 0.94; Ptrend = 0.002) and CVD (HR = 0.74, 95% CI: 0.61, 0.89; Ptrend = 0.001) mortality. We noted 11% lower all-cause mortality and 16% lower CVD mortality risk with high yogurt intake. Cheese intake was associated with 16% lower all-cause mortality and 26% lower CVD mortality risk. Higher intake of high-fat dairy food and milk was not associated with all-cause or CVD mortality. Neither intake of individual dairy products nor intake of total dairy products was significantly associated with overall cancer mortality. High consumption of dairy products, especially yogurt and cheese, may reduce the risk of overall and CVD mortality.