Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis
Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromoso...
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| Published in: | Genomics (San Diego, Calif.) Vol. 41; no. 2; pp. 283 - 285 |
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| Main Authors: | , , , , , , |
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San Diego, CA
Elsevier
15-04-1997
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| Abstract | Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene. |
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| AbstractList | Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene. Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene. (DBO) |
| Author | PHATAK, S REDDY, U. R ALLEN, C BIEGEL, J. A SULMAN, E. P WHITE, P. S NYCUM, L. M |
| Author_xml | – sequence: 1 givenname: U. R surname: REDDY fullname: REDDY, U. R organization: Division of Neurology Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States – sequence: 2 givenname: S surname: PHATAK fullname: PHATAK, S organization: Division of Neurology Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States – sequence: 3 givenname: C surname: ALLEN fullname: ALLEN, C organization: Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, France – sequence: 4 givenname: L. M surname: NYCUM fullname: NYCUM, L. M organization: Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, France – sequence: 5 givenname: E. P surname: SULMAN fullname: SULMAN, E. P organization: Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, France – sequence: 6 givenname: P. S surname: WHITE fullname: WHITE, P. S organization: Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, France – sequence: 7 givenname: J. A surname: BIEGEL fullname: BIEGEL, J. A organization: Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, France |
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| Keywords | Genetic mapping Human Membrane receptor Gene Enzyme Transferases Chromosome A1 Protein-tyrosine kinase |
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| Snippet | Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern... |
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| SubjectTerms | Animals Biological and medical sciences Cell Line Chromosome Mapping Chromosomes, Human, Pair 1 Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells In Situ Hybridization, Fluorescence Receptor Protein-Tyrosine Kinases - genetics Receptor Tyrosine Kinase-like Orphan Receptors Receptors, Cell Surface - genetics Rodentia |
| Title | Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis |
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