Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis

• Published in: Genomics (San Diego, Calif.) Vol. 41; no. 2; pp. 283 - 285
• Main Authors: REDDY, U. R, PHATAK, S, ALLEN, C, NYCUM, L. M, SULMAN, E. P, WHITE, P. S, BIEGEL, J. A
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier 15-04-1997
• Subjects: Animals; Biological and medical sciences; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 1; Classical genetics, quantitative genetics, hybrids; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Receptor Protein-Tyrosine Kinases - genetics; Receptor Tyrosine Kinase-like Orphan Receptors; Receptors, Cell Surface - genetics; Rodentia; Genetic mapping; Human; Membrane receptor; Gene; Enzyme; Transferases; Chromosome A1; Protein-tyrosine kinase
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1997.4653

Ror1 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factor receptors, in particular the Trk family. Southern blot analysis of genomic DNA from somatic cell hybrids revealed that Ror1 is located on chromosome 1. We have mapped the Ror1 gene to chromosome 1p12-p32 using PCR on a somatic cell hybrid panel that subdivides chromosome 1p. We have further localized the gene to chromosome 1p31-p32 by fluorescence in situ hybridization using a PAC clone that contains the Ror1 gene.