Tubuloreticular inclusions in colonic mucosa as diagnostic markers of AIDS

Tubuloreticular inclusions in colonic mucosa as diagnostic markers of AIDS

Tubuloreticular inclusions (TRI) are known to be associated with viral infections and are considered highly specific of the acquired immune deficiency syndrome (AIDS) in the appropriate clinical setting. We describe a homosexual man without any evidence of AIDS who presented with diarrhea. A search...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of gastroenterology Vol. 84; no. 2; p. 195
Main Authors: Ozick, L, Chander, P, Agarwal, A, Soni, A
Format: Journal Article
Language:English
Published: United States 01-02-1989
Subjects:
Acquired Immunodeficiency Syndrome - pathology
Adult
Colon - ultrastructure
Humans
Inclusion Bodies, Viral - ultrastructure
Intestinal Mucosa - ultrastructure
Male
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tubuloreticular inclusions (TRI) are known to be associated with viral infections and are considered highly specific of the acquired immune deficiency syndrome (AIDS) in the appropriate clinical setting. We describe a homosexual man without any evidence of AIDS who presented with diarrhea. A search for the usual pathogens was unsuccessful, but electronmicroscopic examination of colonic mucosa revealed numerous tubuloreticular inclusions. The diarrhea subsided and 2 months later the patient developed Pneumocystis carinni pneumonia. This observation suggests that the detection of TRI in the colonic mucosa can precede the clinical manifestations of AIDS, and these structures can be useful markers for the future development of AIDS.
ISSN:0002-9270
DOI:10.1111/j.1572-0241.1989.tb02509.x