Increased circulating myeloid-derived suppressor cells correlate with cancer stages, interleukin-8 and -6 in prostate cancer

• Published in: International journal of clinical and experimental medicine Vol. 7; no. 10; pp. 3181 - 3192
• Main Authors: Chi, Ning, Tan, Zhaohui, Ma, Kewei, Bao, Lidao, Yun, Zhizhong
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01-01-2014
• Subjects: Original; MDSCs; prostate cancer; IL-8; IL-6
• ISSN: 1940-5901; 1940-5901

Myeloid-derived suppressor cells (MDSCs) are a population of cells which negatively regulate immune response during tumor progression. In this study, we assessed the accumulation of MDSCs (CD33(+)CD11b(+)HLA-DR(-)CD14(-)) in patients with prostate cancer and its clinical relevance.
We tested the frequency of MDSCs in the peripheral blood of patients with prostate cancer or benign prostate hyperplasia and healthy donors. Serumal interleukin-8, -6 and -10 were analyzed. Effects of MDSCs on the T cell response were determined.
MDSCs increased in cancer patients, and there was an association between MDSCs and cancer stages or overall survival. Elevated serumal interleukin-8 and -6 in cancer patients correlated with MDSCs. Moreover, accumulation of MDSCs was associated with defective T cell function.
Our study showed an increased population of MDSCs in patients with prostate cancer. Interleukin-8 and -6 in serum may play a new important role companied with MDSCs in prostate cancer.