Sedimentation analysis of the RNAs isolated from interfering particles of Lassa and Machupo viruses

Vero cells chronically infected with Lassa virus as well as BHK-21 cells chronically infected with Machupo virus produced particles interfering with the replication of homologous, but not heterogeneous viruses. RNAs of standard virus particles contained 4 sedimentation classes of molecules: 28-31 S,...

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Bibliographic Details
Published in:	Acta virologica (Anglickâa verze) Vol. 29; no. 6; p. 455
Main Authors:	Lukashevich, I S, Trofimov, N M, Golubev, V P, Maryankova, R F
Format:	Journal Article
Language:	English
Published:	Slovakia 01-12-1985
Subjects:	Animals Arenaviridae - genetics Arenaviruses, New World - genetics Arenaviruses, New World - physiology Cell Line Cercopithecus aethiops Cricetinae Lassa virus - genetics Lassa virus - physiology RNA, Viral - analysis Viral Interference Virion - analysis Virion - genetics Virus Replication
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Summary:	Vero cells chronically infected with Lassa virus as well as BHK-21 cells chronically infected with Machupo virus produced particles interfering with the replication of homologous, but not heterogeneous viruses. RNAs of standard virus particles contained 4 sedimentation classes of molecules: 28-31 S, 22-24S, 18 S and 4-6 S. The 28-31 S molecules were not present among the RNAs of interfering particles of Lassa and Machupo viruses.
ISSN:	0001-723X