Effects of pentoxifylline on alcohol-induced gastric injury and acid secretion in rats

• Published in: Digestive diseases and sciences Vol. 48; no. 7; pp. 1392 - 1396
• Main Authors: YÖNETCI, Nadir, KÖSEKLI, Mehmet Ali, ÖZÜTEMIZ, A. Ömer, KARAOGLU, Ali Önder, ORUC, Nevin, ERKUS, Muhan, TANYALCIN, Tijen, BATUR, Yucel
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01-07-2003; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Digestive system; Ethanol; Gastric Acid - metabolism; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Gastric Mucosa - pathology; Male; Medical sciences; Nitric Oxide - metabolism; Pentoxifylline - pharmacology; Pharmacology. Drug treatments; Protective Agents - pharmacology; Rats; Stomach Diseases - chemically induced; Stomach Diseases - metabolism; Stomach Diseases - prevention & control; alcohol-induced gastritis; Vasodilator agent; Rat; Complication; Xanthine derivatives; malondialdehyde; Gastric disease; gastric acid secretion; Drug addiction; Stomach; nitric oxide; Ethanol; Secretion; prostaglandin; Rodentia; Biological activity; Gastritis; Pentoxifylline; Vertebrata; Experimental disease; Mammalia; Acids; Cytoprotector; Food intake; Animal; Digestive diseases
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1023/A:1024290615796

We aimed to evaluate the protective effects of pentoxifylline on alcohol-induced gastric injury, its relation with nitric oxide and prostaglandin synthesis, as well as gastric acidity in rats. Acute gastric mucosal injury was induced by intragastric infusion of 2 ml 98% alcohol. Pentoxifylline was given at 100 mg/kg intraperitoneally. Indomethacin and N(G)-nitro-L arginine were used to inhibit prostaglandin and nitric oxide synthesis, respectively. Macroscopic and microscopic gastric injuries were evaluated. Gastric pH, tissue malondialdehyde levels, oxidized and reduced glutathion (GSSG/GSH) levels, and effects of pentoxifylline on gastric acid output were measured. Pentoxifylline pretreatment significantly reduced macroscopic and microscopic gastric injury. Malondialdehyde level was lower in pentoxifylline treated rats (351.1 +/- 94.1 nmol/g vs 624.3 +/- 234.2 nmol/g). Pentoxifylline has a protective role on alcohol-induced gastric mucosal injury in rats. This effect is not related to synthesis of prostaglandins and changes in gastric acidity but does seem to be related to nitric oxide-mediated pathways. In contrast, pentoxifylline increases gastric acid output significantly.