Helicobacter pylori-induced gastritis may contribute to occurrence of postprandial symptomatic hypoglycemia

• Published in: Digestive diseases and sciences Vol. 44; no. 9; pp. 1837 - 1842
• Main Authors: ACBAY, O, CELIK, A. F, KADIOGLU, P, GOKSEL, S, GUNDOGDU, S
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01-09-1999; Springer Nature B.V
• Subjects: Adult; Biological and medical sciences; Blood Glucose - analysis; Digestive system; Eating - physiology; Female; Gastritis - complications; Gastritis - microbiology; Gastritis - physiopathology; Helicobacter Infections; Helicobacter pylori; Humans; Hypoglycemia - blood; Hypoglycemia - etiology; Insulin - blood; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Pain Measurement; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Human; Biochemical analysis; Spirillales; Induction; Postprandial; Spirillaceae; Metabolic diseases; Biochemistry; Glucose; Hypoglycemia; Gastritis; Helicobacter pylori; Risk factor; Digestive diseases; Bacteria; Comparative study; Gastric disease
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1023/A:1018842606388

In our clinical experience, postprandial symptomatic hypoglycemic (PSH) patients with H. pylori gastritis showed a substantial improvement in their hypoglycemic symptoms after the eradication of H. pylori. Therefore, in this study we have investigated whether H. pylori gastritis may contribute to the occurrence of PSH. For this purpose, we have evaluated the following parameters in 12 PSH patients with H. pylori gastritis before and one month after the eradication therapy: (1) the number and severity of PSH attacks that occurred in a one-month period using a 30-day diary, (2) the total symptom score following a mixed meal using a visual analog scale questionnaire (VASQ), and (3) the glucose and insulin responses to the mixed meal. After the eradication of H. pylori, the serum insulin responses at 30 and 60 min decreased (P < 0.001 in both), whereas the plasma glucose levels at 150, 180 and 210 min increased significantly (P < 0.001 for 180 min and P < 0.01 in others) following the mixed meal. The number and severity score of PSH attacks that occurred in a one-month period and the area under curve for symptom score in VASQ decreased significantly (P < 0.001 in all). These results suggest that H. pylori gastritis may contribute to the occurrence of PSH.