Diffuse pontine astrocytoma with lipocytic differentiation

A 7-year-old boy was treated with radiation and chemotherapy for a diffuse pontine glioma. At autopsy, 8 months after diagnosis, the tumor was a diffuse grade II fibrillary astrocytoma with prominent lipocytic differentiation. Literature review suggests that lipocytic differentiation in low-grade as...

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Bibliographic Details
Published in:	The Ochsner journal Vol. 12; no. 3; pp. 244 - 248
Main Authors:	Craver, Randall, Arcement, Christopher, Chrisentery Singleton, Tammuella
Format:	Journal Article
Language:	English
Published:	United States Ochsner Clinic Foundation Academic Center - Publishing Services 2012 the Academic Division of Ochsner Clinic Foundation
Subjects:	Age Brain cancer Case Reports and Clinical Observations Chemotherapy Cysts Cytoplasm Gangrene Glioma Medical prognosis NMR Nuclear magnetic resonance Patients Sepsis Streptococcus infections Tumors pontine glioma lipoastrocytoma Astrocytoma
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Summary:	A 7-year-old boy was treated with radiation and chemotherapy for a diffuse pontine glioma. At autopsy, 8 months after diagnosis, the tumor was a diffuse grade II fibrillary astrocytoma with prominent lipocytic differentiation. Literature review suggests that lipocytic differentiation in low-grade astrocytomas occurs in a variety of patient ages, anatomic sites, grades, and astrocytic subtypes. Although the majority of low-grade lipoastrocytomas have behaved benignly, this child's lipoastrocytoma was the underlying cause of death. This outcome suggests that the outcomes of low-grade lipoastrocytic tumors may be expected to be the same as the underlying tumor subtype.
ISSN:	1524-5012