HEPATIC FATTY ACID PROFILE OF RATS FED A TRIHEPTANOIN-BASED KETOGENIC DIET

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 32; no. 1; pp. 265 - 269
• Main Authors: Vieira de Melo, Ingrid Sofia, Da Rocha Ataide, Terezinha, Lima de Oliveira, Suzana, Bezerra Bueno, Nassib, Duarte de Freitas, Johnnatan, Goulart Sant'Ana, Antônio Euzébio
• Format: Journal Article
• Language: English
• Published: Spain Grupo Arán 01-07-2015
• Subjects: Animals; Diet, Ketogenic; Dietary Supplements; Fatty Acids - metabolism; Liver - metabolism; Male; Metabolomics - methods; Nutrition & Dietetics; Rats; Triglycerides - administration & dosage; Fatty acid profile; Triheptanoína; Ratones Wistar; Ácidos grasos; Trienantin; Medium-chain triacylglycerols; Ketogenic diet
• ISSN: 1699-5198; 1699-5198
• DOI: 10.3305/nh.2015.32.1.9033

the aim of this study was to evaluate the influence of consumption of a ketogenic diet supplemented with triheptanoin, a medium-chain anaplerotic triacylglycerol, on the liver fatty acid profile of Wistar rats.
three groups of male Wistar rats (n = 10) were submitted to an AIN-93 control diet, a triheptanoin- based ketogenic diet, or a soybean oil-based ketogenic diet for 60 days. Excised livers were subjected to lipid extraction and methylation to obtain fatty acids methyl esters, which were subjected to gas chromatography- mass spectrometry.
compared to the rats fed the control diet, those fed ketogenic diets showed a significant reduction in the concentrations of 9-hexadecenoic and 9-octadecenoic acids, whereas those fed triheptanoin showed increased levels of octadecanoic acid.
changes in the liver fatty acid profiles of the rats fed a triheptanoin-based or a soybean oil-based ketogenic diet did not seem to be related to the dietary fat source, but rather to the characteristics of the ketogenic diets themselves.