Glucagon test in insulinoma: Is it useful?

Diagnosis of endogenous hyperinsulinism caused by insulinoma is based on confirmation of hypoglycemia during the symptoms associated to elevated insulin levels. Patients with insulinoma may demonstrate an excessive insulin response and subsequent hypoglycemia after 1 mg of glucagon iv injection. Glu...

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Bibliographic Details
Published in:	Journal of endocrinological investigation Vol. 35; no. 6; pp. 570 - 572
Main Authors:	Felício, J. S., Martins, C. L. L. P., Mileo, K. B., Semer, M., Kalinin, L., Nery, M., Machado, M. C. C., Liberman, B.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-06-2012
Subjects:	Adult Aged Blood Glucose - metabolism Endocrinology Female Glucagon Hormones Humans Hyperinsulinism - blood Hypoglycemia - diagnosis Insulin - metabolism Insulinoma - diagnosis Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Pancreatic Neoplasms - diagnosis Radioimmunoassay Young Adult Hyperinsulinism hypoglycemia insulinoma
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Summary:	Diagnosis of endogenous hyperinsulinism caused by insulinoma is based on confirmation of hypoglycemia during the symptoms associated to elevated insulin levels. Patients with insulinoma may demonstrate an excessive insulin response and subsequent hypoglycemia after 1 mg of glucagon iv injection. Glucagon test was performed in 11 patients with insulinoma before therapy and in 4 after therapy. Our study suggests that the presence of plasma glucose levels less than 55 mg/dl and below baseline at time 120 min of glucagon test strongly reinforce the diagnosis of insulinoma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0391-4097 1720-8386
DOI:	10.3275/7879