3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors

A new class of inhibitors of HIV-1 integrase has been optimized to provide selective and highly efficient strand transfer inhibition.

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 19; no. 7; pp. 1930 - 1934
Main Authors:	Donghi, Monica, Kinzel, Olaf D, Summa, Vincenzo
Format:	Journal Article
Language:	English
Published:	England 01-04-2009
Subjects:	Animals HIV Integrase - metabolism HIV Integrase Inhibitors - chemical synthesis HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - pharmacokinetics HIV-1 - drug effects Human immunodeficiency virus 1 Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacokinetics Rats Structure-Activity Relationship
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Description
Summary:	A new class of inhibitors of HIV-1 integrase has been optimized to provide selective and highly efficient strand transfer inhibition.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.02.055