Recovery after a traumatic brain injury depends on diurnal variations Effect of cystatin C

Many studies indicate that the hour of the day at which the onset of stroke occurs is very important in patient recovery. Furthermore, multiple studies have been conducted which show that ischemia in rats produces different magnitudes of injury depending on the hour of the day at which it was induce...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience letters Vol. 400; no. 1-2; pp. 21 - 24
Main Authors:	MARTINEZ-VARGAS, Marina, GONZALEZ-RIVERA, Ruben, SOTO-NUNEZ, Maribel, CISNEROS-MARTINEZ, Marina, HUERTA-SAQUERO, Alejandro, MORALES-GOMEZ, Julio, MOLINA-GUARNEROS, Juan, NAVARRO, Luz
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier 29-05-2006
Subjects:	Analysis of Variance Animals Biological and medical sciences Brain Injuries - drug therapy Brain Injuries - physiopathology Circadian Rhythm Cystatin C Cystatins - administration & dosage Disease Models, Animal Drug Administration Schedule Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Neuroprotective Agents - administration & dosage Rats Rats, Wistar Recovery of Function - drug effects Trauma Severity Indices Traumas. Diseases due to physical agents Cystatin Neuroprotection Rat Enzyme Rodentia Central nervous system Cathepsins Biological rhythm Circadian rhythm Diurnal variation Trauma Encephalon Peptidases Vertebrata Cathepsin Mammalia Functional recovery Animal Hydrolases Lesion Brain vulnerability
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Many studies indicate that the hour of the day at which the onset of stroke occurs is very important in patient recovery. Furthermore, multiple studies have been conducted which show that ischemia in rats produces different magnitudes of injury depending on the hour of the day at which it was induced. Using a traumatic brain injury (TBI) model, we analyzed the effect of the time of day on the recovery of rats and obtained a higher survival rate if TBI was induced at 01:00 h as compared with TBI induced at 13:00 h. We also analyzed the effect of the protease inhibitor cystatin C (CC) on the recovery of rats from TBI and found that it increased mortality and bleeding, and that these effects were more pronounced at 13:00 h.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2006.02.010