Reactive thrombocytosis in children

• Published in: Turkish journal of pediatrics Vol. 55; no. 4; pp. 411 - 416
• Main Authors: Özcan, Celal, Sayli, Tülin Revide, Kosan-Çulha, Vildan
• Format: Journal Article
• Language: English
• Published: Turkey Hacettepe University Faculty of Medicine 01-07-2013
• Subjects: Adolescent; Child; Child, Preschool; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant, Newborn; Infection - complications; Inflammation - complications; Male; Platelet Count; Retrospective Studies; Risk Factors; Severity of Illness Index; Thrombocytosis - blood; Thrombocytosis - diagnosis; Thrombocytosis - etiology
• ISSN: 0041-4301

The aim of this study was to evaluate the causes of thrombocytosis, which was defined as a platelet count greater than 500 x 10(9)/L, and to compare the groups with mild and severe thrombocytosis. A total of 484 patients were evaluated for the etiology of thrombocytosis. Patients with a platelet count between 500-800 x 10(9)/L were considered to have mild thrombocytosis, while those with a count of ≥800 x 10(9)/L were considered as having severe thrombocytosis. Of 484 patients included, 63% had thrombocytosis due to an infectious disease, 11.4% had a chronic inflammatory condition, 8.5% had anemia, and 5.2% had tissue injury. The frequency of chronic inflammation was higher in the severe thrombocytosis group compared to the mild thrombocytosis group (p=0.006). In conclusion, severe infections and chronic inflammatory conditions should be considered in the differential diagnosis of a patient with severe thrombocytosis.