Metastatic uterine serous carcinoma originating in an endometrial polyp : A report of 2 cases

Endometrial carcinoma is the most common cancer of the female genital tract. Two histologic variants have been described: an estrogen-dependent form and a more aggressive, non-estrogen-dependent form, which includes uterine serous carcinoma. Two cases of uterine serous carcinoma were confined to an...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of reproductive medicine Vol. 50; no. 3; pp. 209 - 212
Main Authors:	CHILDS, Alex J, BURKE, James J, PERRY, Michelle Y, GALLUP, Donald G
Format:	Journal Article
Language:	English
Published:	Saint-Louis, MO Science 01-03-2005
Subjects:	Abdominal Pain - etiology Aged Biological and medical sciences Constipation Cystadenocarcinoma, Serous - etiology Cystadenocarcinoma, Serous - pathology Cystadenocarcinoma, Serous - surgery Endometrial Neoplasms - pathology Fatal Outcome Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Neoplasm Invasiveness Polyps - pathology Prognosis Tumors Uterine Neoplasms - etiology Uterine Neoplasms - pathology Uterine Neoplasms - surgery polyps uterine cancer Gynecology Uterus cancer Metastasis Malignant tumor Obstetrics Endometrial carcinoma Female genital diseases Case study Female genital system Serous carcinoma Uterine diseases Advanced stage Endometrium carcinoma Endometrium Polyp
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Endometrial carcinoma is the most common cancer of the female genital tract. Two histologic variants have been described: an estrogen-dependent form and a more aggressive, non-estrogen-dependent form, which includes uterine serous carcinoma. Two cases of uterine serous carcinoma were confined to an endometrial polyp without myometrial invasion and were widely metastatic. One patient presented with abdominal pain and constipation, while the other patient was asymptomatic. Both patients had elevated CA-125 levels. At the time of surgery, these patients were found to have extensive carcinomatosis and underwent surgical staging procedures that required bowel resections. Pathology showed metastatic disease originating in a small focus of serous adenocarcinoma at the tip of an endometrial polyp. Combination chemotherapy was planned; but 1 of the patients died prior to its initiation. These cases emphasize the aggressive nature of uterine serous carcinoma despite insignificant myometrial invasion.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0024-7758