Two cases of chronic lymphoproliferative disorders in psoriatic patients treated with cyclosporine : hairy cell leukemia and Waldenstrom macroglobulinemia

• Published in: EJD. European journal of dermatology Vol. 15; no. 4; pp. 271 - 273
• Main Authors: FOZZA, Claudio, DORE, F, BONFIGLI, S, PODDA, L, LONGINOTTI, M
• Format: Journal Article
• Language: English
• Published: Montrouge Libbey-Eurotext 01-07-2005
• Subjects: Adult; Biological and medical sciences; Cyclosporine - administration & dosage; Cyclosporine - adverse effects; Cyclosporine - therapeutic use; Dermatology; Diagnosis, Differential; Drug Administration Schedule; Female; Hematologic and hematopoietic diseases; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulinopathies; Immunopathology; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Leukemia, Hairy Cell - complications; Leukemia, Hairy Cell - diagnosis; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Psoriasis - complications; Psoriasis - drug therapy; Psoriasis. Parapsoriasis. Lichen; Waldenstrom Macroglobulinemia - complications; Waldenstrom Macroglobulinemia - diagnosis; Human; cyclosporine; Immunopathology; Skin disease; Psoriasis; Dermatology; Malignant hemopathy; Disorder; HCL; Chronic; Hairy cell leukemia; Treatment; Immunoglobulinopathy; Lymphoproliferative syndrome; Ciclosporin; Immunosuppressive agent; Waldenstrom macroglobulinemia
• ISSN: 1167-1122; 1952-4013

The real risk of lymphoproliferative disease in psoriatic patients has not yet been defined. Two explanations can be given for the occurrence of these malignancies: the broad immune activation typical of psoriasis and the administration of an immuno-suppressive treatment. A few studies describing the development of non Hodgkin lymphomas in psoriatic patients undergoing cyclosporine A have been published, but data about the occurrence of chronic lymphoproliferative disorders have never been reported. Here we describe the occurrence of hairy cell leukemia and Waldenstrom macroglobulinemia in two psoriatic patients treated with cyclosporine A. It remains unclear in our cases of chronic lymphoproliferative disease, as well as in the reported cases of psoriatic patients who develop lymphomas, whether psoriasis or the immunosuppressive treatment could play a role, although it is not possible to exclude a synergism between these factors.