Monocyte functional defects in rheumatoid arthritis

Monocytes derived from peripheral blood of patients with rheumatoid arthritis (RA) had a marked defect in their chemotactic and phagocytic activity. The chemotactic defect resides at a cellular level, while the phagocytic defect is serum-dependent. Both defects could be of importance in the pathogen...

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Bibliographic Details
Published in:	Allergologia et immunopathologia Vol. 10; no. 5; p. 353
Main Authors:	Jiménez López, A, Olmos Martínez, J M, García Palomo, J D, De Dios Martín, B, Pedraz García, M J, Lorente Toledano, F
Format:	Journal Article
Language:	English
Published:	Spain 01-01-1982
Subjects:	Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - immunology Chemotaxis, Leukocyte Cytotoxicity Tests, Immunologic Humans Leukocyte Migration-Inhibitory Factors - blood Monocytes - immunology Phagocytosis T-Lymphocytes, Cytotoxic - immunology
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Summary:	Monocytes derived from peripheral blood of patients with rheumatoid arthritis (RA) had a marked defect in their chemotactic and phagocytic activity. The chemotactic defect resides at a cellular level, while the phagocytic defect is serum-dependent. Both defects could be of importance in the pathogenicity of RA and the susceptibility to infection such patients show. Finally, monocytes were found to have a negative influence over spontaneous cytotoxicity mediated by T lymphocytes.
ISSN:	0301-0546