Murine lymph nodes in response to the local administration of dextran sulphate

In mice a single injection of 4 mg of Dextran sulphate within a few days produces an enlargement of area draining lymph nodes and activates basophils/mast cells. This activation is manifested by many-fold increase of mast cell number per lymph node, degranulation of mast cells and appearance of youn...

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Bibliographic Details
Published in:	Archivum Immunologiae et Therapiae Experimentalis Vol. 38; no. 5-6; p. 475
Main Authors:	Włodarski, K, Jankowska, E, Marciniak, M, Gryglas, P, Grzesik, A
Format:	Journal Article
Language:	English
Published:	Switzerland 1990
Subjects:	Animals Dextran Sulfate - administration & dosage Dextran Sulfate - pharmacology Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Activation - drug effects Macrophage Activation - drug effects Male Mast Cells - drug effects Mast Cells - immunology Mast Cells - pathology Mice Mice, Inbred Strains Microscopy, Electron T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology
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Summary:	In mice a single injection of 4 mg of Dextran sulphate within a few days produces an enlargement of area draining lymph nodes and activates basophils/mast cells. This activation is manifested by many-fold increase of mast cell number per lymph node, degranulation of mast cells and appearance of young, immature mast cells capable to synthetize new granules. In contrast to the lymph nodes, the Dextran-injected connective tissue mast cells remained unchanged. This suggest that Dextran sulphate directly activates lymph node mast cells, probably by activation of T-cell suppressor or macrophages.
ISSN:	0004-069X