KAI1/CD82 expression as a prognosic factor in sporadic colorectal cancer

• Published in: Anticancer research Vol. 21; no. 5; p. 3581
• Main Authors: Muneyuki, T, Watanabe, M, Yamanaka, M, Shiraishi, T, Isaji, S
• Format: Journal Article
• Language: English
• Published: Greece 01-09-2001
• Subjects: Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Neoplasm - biosynthesis; Antigens, Surface - biosynthesis; Colorectal Neoplasms - immunology; Colorectal Neoplasms - pathology; Female; Humans; Immunohistochemistry; Kangai-1 Protein; Male; Membrane Glycoproteins - biosynthesis; Middle Aged; Multivariate Analysis; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins; Survival Rate
• ISSN: 0250-7005

Since its identification as a suppressor gene for prostate cancer metastasis, down-regulation of KAI1/CD82 in a variety of malignancies has been reported.
Using immunohistochemistry, we examined KAI1/CD82 expression in surgical specimens obtained from 70 patients with advanced colorectal cancer and its correlation with clinicopathological factors, to clarify their prognostic significance.
KAI1/CD82 expression was positive in 55% of the 70 colorectal cancers. There were statistically significant correlations between KAI1/CD82 expression and Dukes' stage, venous invasion, lymph node metastasis, tumor differentiation and liver metastasis. The significant correlation between KAI1/CD82 expression and outcome among patients with Dukes' C cancer (p=0.024) is particularly noteworthy. On multivariate analysis, KAI1/CD82 expression and Dukes' stage were identified as significant and independent prognostic factors (p=0.006 and 0.045, respectively).
KAI1/CD82 expression closely correlates with clinicopathological factors for colorectal cancers. KAI1/CD82 expression appears to be a useful prognostic marker.