Metabolic diversions in the oxidative metabolism of hepatic and neuronal systems of rat (Wistar strain) under induced benthiocarb stress

Metabolic diversions in oxidative metabolism of hepatic and neuronal systems of rat were noticed during induced benthiocarb stress. The inhibition of dehydrogenases indicates disturbed mitochondrial integrity, and reduction in cytochrome-C-oxidase suggests possible respiratory distress. The drop in...

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Bibliographic Details
Published in:	Biochemistry international Vol. 19; no. 3; p. 477
Main Authors:	Babu, G R, Reddy, G R, Srinivas, P N, Chetty, C S
Format:	Journal Article
Language:	English
Published:	Australia 01-09-1989
Subjects:	Animals Brain - drug effects Brain - enzymology Insecticides - toxicity Liver - drug effects Liver - enzymology Male Oxidoreductases - antagonists & inhibitors Rats Rats, Inbred Strains Stress, Physiological - enzymology Thiocarbamates
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Summary:	Metabolic diversions in oxidative metabolism of hepatic and neuronal systems of rat were noticed during induced benthiocarb stress. The inhibition of dehydrogenases indicates disturbed mitochondrial integrity, and reduction in cytochrome-C-oxidase suggests possible respiratory distress. The drop in ATPases and PNPPase indicates the prevalence of energy crisis. The increased specific activities of NADP+ dependent dehydrogenases suggests augmented lipid biosynthesis in the wake of impaired oxidative metabolism.
ISSN:	0158-5231