The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis

The effect of Cannabis sativa on trypanosome-infected rats was examined. An aqueous extract of the seeds administered at a dose of 50 mg/kg/d cured animals infected with Trypanosome brucei brucei of blood stream parasites. Six fractions eluted from the crude extract by column chromatography were ass...

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Bibliographic Details
Published in:	Veterinary and human toxicology Vol. 36; no. 6; p. 522
Main Authors:	Nok, A J, Ibrahim, S, Arowosafe, S, Longdet, I, Ambrose, A, Onyenekwe, P C, Whong, C Z
Format:	Journal Article
Language:	English
Published:	United States 01-12-1994
Subjects:	Animals Cannabinoids - administration & dosage Cannabinoids - isolation & purification Cannabinoids - pharmacology Cannabinoids - therapeutic use Cannabis - chemistry Chemical Fractionation Chromatography Mice Parasitemia - drug therapy Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Seeds - chemistry Trypanosoma brucei brucei - drug effects Trypanosomiasis, African - drug therapy
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Summary:	The effect of Cannabis sativa on trypanosome-infected rats was examined. An aqueous extract of the seeds administered at a dose of 50 mg/kg/d cured animals infected with Trypanosome brucei brucei of blood stream parasites. Six fractions eluted from the crude extract by column chromatography were assessed for trypanocidal properties. Of these, only 2 fractions retained trypanocidal activity by curing mice infected with T brucei brucei.
ISSN:	0145-6296