Immunohistochemical detection of hepatitis C virus related C100-3 and core antigens in formalin-fixed liver tissue

HCV C100-3 non-structural and core proteins have been detected by immunohistochemical methods on paraffin-embedded tissue sections using monoclonal antibodies in 22 cases of chronic hepatitis C. C100-3 protein was detected in cytoplasm and nuclei of hepatocytes whereas core protein was only detected...

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Bibliographic Details
Published in:	Cellular and molecular biology (Noisy-le-Grand, France) Vol. 42; no. 4; p. 557
Main Authors:	Chamlian, A, Benkoël, L, Sahel, J, Cherid, A, Brisse, J, Ikoli, J F, Lambert, R, De Lamballerie, X
Format:	Journal Article
Language:	English
Published:	France 01-06-1996
Subjects:	Antigens, Viral Fixatives - chemistry Formaldehyde - chemistry Hepacivirus - immunology Hepacivirus - isolation & purification Hepatitis C - immunology Hepatitis C - pathology Hepatitis C - virology Hepatitis C Antigens - analysis Humans Immunohistochemistry Liver - pathology Liver - virology Viral Core Proteins - analysis Viral Nonstructural Proteins - analysis
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Summary:	HCV C100-3 non-structural and core proteins have been detected by immunohistochemical methods on paraffin-embedded tissue sections using monoclonal antibodies in 22 cases of chronic hepatitis C. C100-3 protein was detected in cytoplasm and nuclei of hepatocytes whereas core protein was only detected in nuclei. The specificity of the nuclear localization of HCV antigens was discussed in relation to cross-reactivity of the anti core antibody with host-derived GOR antigen.
ISSN:	0145-5680