Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15

The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid derivatives substituted on carbon-15. On...

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Bibliographic Details
Published in:	Brazilian journal of medical and biological research Vol. 22; no. 9; p. 1127
Main Authors:	Davino, S C, Giesbrecht, A M, Roque, N F
Format:	Journal Article
Language:	English
Published:	Brazil 1989
Subjects:	Bacillus cereus - drug effects Brazil Chemical Phenomena Chemistry Diterpenes - pharmacology Fungi - drug effects Microbial Sensitivity Tests Plant Extracts - pharmacology Plants, Medicinal Staphylococcus aureus - drug effects Staphylococcus epidermidis - drug effects Brazil
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Summary:	The antibacterial and antifungic activities of two kaurenic acids, ent kaurenoic acid and cinnamoylgrandifloric acid isolated from a hexane extract of aerial parts of Mikania laevigata, were investigated and compared with the activities of other kaurenic acid derivatives substituted on carbon-15. Only acetylgrandifloric acid (ent-kaur-16-en-15 alpha-acetyloxy-19-oic) and its epimer xylopic acid (ent-kaur-16-en-15 beta-acetyloxy-19-oic) displayed significant antibacterial activity at concentrations greater than or equal to 250 micrograms/ml, the 15 alpha epimer being the most active.
ISSN:	0100-879X