Subsets of T lymphocytes in relation to T lymphocyte function in multiple sclerosis

• Published in: Clinical and experimental immunology Vol. 61; no. 3; pp. 548 - 555
• Main Authors: CRAIG, J. C, HAWKINS, S. A, SWALLOW, M. W, LYTTLE, J. A, PATTERSON, V. H, MERRETT, J. D, HAIRE, M
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01-09-1985
• Subjects: Adrenocorticotropic Hormone - therapeutic use; Antibodies, Viral - analysis; Antigens, Viral - immunology; Biological and medical sciences; Cytotoxicity, Immunologic; Epstein-Barr virus; Female; Herpesvirus 4, Human - immunology; Humans; Male; Medical sciences; Multiple Sclerosis - drug therapy; Multiple Sclerosis - immunology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; T-Lymphocytes - classification; T-Lymphocytes - immunology; Multiple sclerosis; Nervous system diseases; Immunology; T-Lymphocyte
• ISSN: 0009-9104; 1365-2249

T lymphocyte control of Epstein-Barr virus (EBV) infection of autologous B lymphocytes was examined in parallel to the enumeration of subpopulations of mononuclear cells in 22 multiple sclerosis (MS) patients and in 22 healthy individuals. All were seropositive for EBV. The incidence of lack of T cell control was significantly higher in patients than in controls, confirming previous published work. In the present study, we have shown in addition a significantly reduced proportion of OKT8+ cells and a significantly increased ratio of OKT4/OKT8 cells in the group of patients with lack of control. The findings point to abnormal immunoregulation in MS.