Disseminated metastasis of neuroblastomatous component in immature mediastinal teratoma: a case report

• Published in: Anticancer research Vol. 20; no. 1B; p. 527
• Main Authors: Ohtsuka, M, Satoh, H, Inoue, M, Yazawa, T, Yamashita, Y T, Sekizawa, K, Hasegawa, S
• Format: Journal Article
• Language: English
• Published: Greece 01-01-2000
• Subjects: Adolescent; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers, Tumor - analysis; Bleomycin - administration & dosage; Brain Neoplasms - pathology; Brain Neoplasms - secondary; Cell Lineage; Cisplatin - administration & dosage; Combined Modality Therapy; Disease Progression; Fatal Outcome; Humans; Lung Neoplasms - pathology; Lung Neoplasms - secondary; Male; Mediastinal Neoplasms - chemistry; Mediastinal Neoplasms - drug therapy; Mediastinal Neoplasms - pathology; Mediastinal Neoplasms - surgery; Neuroblastoma - chemistry; Neuroblastoma - drug therapy; Neuroblastoma - pathology; Neuroblastoma - secondary; Neuroblastoma - surgery; Phosphopyruvate Hydratase - analysis; Skull Neoplasms - pathology; Skull Neoplasms - secondary; Teratoma - drug therapy; Teratoma - pathology; Teratoma - surgery; Thymus Neoplasms - chemistry; Thymus Neoplasms - drug therapy; Thymus Neoplasms - pathology; Thymus Neoplasms - surgery; Vinblastine - administration & dosage
• ISSN: 0250-7005

A 17-year-old man with high levels of serum AFP and hCG was diagnosed as having primary mediastinal GCT. Cisplatin-based chemotherapy decreased the biomarkers, but the mass showed further growth. Pathological examination of the resected mass revealed a mixture of immature and mature teratomas. Six months after the surgery, the patient died of a dissemination of neuroblastomatous cells, which were similar to those in the immature neural component of the primary tumor. A disseminated metastasis of neuroblastoma in immature mediastinal teratoma is a rare complication. Serum NSE can be a useful marker in detecting the metastasis.