Intraosseous salivary tissue : Jawbone examples of choristomas, hamartomas, embryonic rests, and inflammatory entrapment : Another histogenetic source for intraosseous adenocarcinoma

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 90; no. 2; pp. 205 - 217
• Main Authors: BOUQUOT, J. E, GNEPP, D. R, DARDICK, I, HIETANEN, J. H. P
• Format: Journal Article
• Language: English
• Published: St. Louis, MO Elsevier 01-08-2000
• Subjects: Biological and medical sciences; Choristoma - pathology; Dentistry; Diagnosis, Differential; Hamartoma - pathology; Humans; Jaw Diseases - pathology; Jaw Neoplasms - diagnosis; Medical sciences; Osteitis - diagnosis; Otorhinolaryngology. Stomatology; Salivary Gland Neoplasms - diagnosis; Salivary Glands; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Pseudotumor; Adenocarcinoma; Choristoma; Bone marrow disease; Histopathology; Bone marrow; ENT disease; Benign neoplasm; Diagnosis; Localization; Maxillary disease; Human; Mandible; Stomatology; Superior maxillary; Dental disease; Maxillofacial; Alveolar bone; Exploration; Salivary gland; Malignant tumor; Hamartoma; Radiography; Salivary gland disease; Odontogenic tumor
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1067/moe.2000.107058

Hundreds of primary salivary neoplasms have been found to be completely enclosed within the marrow spaces of the maxilla and mandible, yet nonneoplastic salivary tissue has never been convincingly identified within marrow, either separately or adjacent to such neoplasms. This situation has forced the acceptance of an inherently awkward odontogenic origin for all intramedullary salivary carcinomas and adenomas.
The purpose of this study was to microscopically evaluate a large number of maxillofacial marrow samples for the presence of intramedullary salivary tissue.
We microscopically reviewed 5034 maxillofacial bone samples from the Latvala Inflammatory Bone Registry for evidence of heterotopic salivary inclusions within the marrow tissues. Contributing surgeons were contacted for each identified case of intraosseous salivary tissue to assure that all submitted tissue was removed from within the marrow spaces rather than from overlying soft tissue.
Thirteen of 5034 marrow samples (0.3%) contained heterotopic acinic hamartomas, salivary choristomas, embryonic salivary rests, or entrapped surface glands. Four additional hamartomas of the condyle are described. We report also the chance finding of incipient odontogenic epithelial neoplasms (n = 6) and odontogenic epithelial rests (n = 84) within the fatty marrow and outside the periodontal ligament spaces, confirming that not all odontogenic neoplasms are necessarily of periodontal ligament origin.
The frequency rate for salivary choristomas, hamartomas, embryonic rests, and displaced surface glands within alveolar bone is no less than 2.6 of 1000 biopsied marrow samples. This provides an additional and quite logical histogenetic explanation for the presence of intraosseous salivary neoplasms.