Non-Hodgkin's lymphoma in a neonate with Down's syndrome. Case report and literature review

We report a 3 1/2-week-old male infant with Down's syndrome who presented with abdominal distention, ascites, and eosinophilia and was subsequently diagnosed as having an abdominal non-Hodgkin's lymphoma of T-cell type. Because of the unusual association of these two conditions, especially...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of pediatric hematology/oncology Vol. 11; no. 2; p. 186
Main Authors:	Lorenzana, A N, Schorin, M A
Format:	Journal Article
Language:	English
Published:	United States 1989
Subjects:	Abdominal Neoplasms - complications Down Syndrome - complications Eosinophilia - complications Humans Infant Infant, Newborn Lymphoma, Non-Hodgkin - complications Male T-Lymphocytes
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We report a 3 1/2-week-old male infant with Down's syndrome who presented with abdominal distention, ascites, and eosinophilia and was subsequently diagnosed as having an abdominal non-Hodgkin's lymphoma of T-cell type. Because of the unusual association of these two conditions, especially at this early age, the literature was reviewed regarding the possible oncogenic mechanisms in Down's syndrome patients and the various malignancies associated with this condition. Non-Hodgkin's lymphoma is discussed briefly with emphasis on its possible etiologic mechanisms and predisposing conditions, especially the immunodeficiency states. Because this infant presented with non-Hodgkin's lymphoma at an early age, it is considered unlikely that an immunoaberration is responsible. Also, a short discussion of this patient's peripheral and bone marrow eosinophilia is given, implicating a T-cell product (e.g., eosinophil differentiation factor) as the putative pathophysiologic mechanism.
ISSN:	0192-8562