Successful T cell-depleted allogeneic bone marrow transplantation in a child with recurrent multiple extramedullary plasmacytomas

Multiple plasmacytomas with IgA paraproteinemia, a low grade lymphoid neoplasm of differentiated B cells rarely seen in the young, were encountered in a 10-year-old child. T cell-depleted allogeneic bone marrow transplantation (BMT) was performed because of progressive disease despite chemotherapy....

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Bibliographic Details
Published in:	Bone marrow transplantation (Basingstoke) Vol. 10; no. 4; p. 381
Main Authors:	Or, R, Mehta, J, Naparstek, E, Okon, E, Cividalli, G, Slavin, S
Format:	Journal Article
Language:	English
Published:	England 01-10-1992
Subjects:	Bone Marrow Transplantation - immunology Child Female Graft vs Host Reaction - immunology Humans Lymphocyte Depletion Multiple Myeloma - surgery Recurrence T-Lymphocytes - immunology T-Lymphocytes - transplantation Transplantation, Homologous
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Summary:	Multiple plasmacytomas with IgA paraproteinemia, a low grade lymphoid neoplasm of differentiated B cells rarely seen in the young, were encountered in a 10-year-old child. T cell-depleted allogeneic bone marrow transplantation (BMT) was performed because of progressive disease despite chemotherapy. Donor T cells were infused after transplantation in gradually increasing numbers to achieve a graft-versus-tumor effect. Complete eradication of all tumor masses was achieved following BMT with normalization of serum immunoglobulin levels. The patient remains in complete remission 4 years after BMT. Allogeneic BMT should be considered early in the course of low-grade lymphoid malignancy in the younger age group.
ISSN:	0268-3369