Ileal inhibition and modulation of carbachol-stimulated proximal small intestinal motor functions in humans

Carbohydrates within the distal small intestine inhibit endogenously stimulated proximal gastrointestinal motor activity and induced an interdigestive-like pattern in humans. In order to further investigate the intermediary mechanisms of the ileal inhibitory effects, we intubated eight healthy volun...

Full description

Saved in:

Bibliographic Details
Published in:	Zeitschrift für Gastroenterologie Vol. 34; no. 12; p. 791
Main Authors:	Gröger, G, Cherian, L, Goebell, H, Layer, P
Format:	Journal Article
Language:	English
Published:	Germany 01-12-1996
Subjects:	Adult Carbachol - pharmacology Cholinergic Agonists - pharmacology Cholinergic Fibers - drug effects Dietary Carbohydrates - metabolism Female Gastrointestinal Motility - drug effects Humans Ileum - innervation Infusions, Intravenous Male Neural Inhibition - drug effects
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Carbohydrates within the distal small intestine inhibit endogenously stimulated proximal gastrointestinal motor activity and induced an interdigestive-like pattern in humans. In order to further investigate the intermediary mechanisms of the ileal inhibitory effects, we intubated eight healthy volunteers with an oroileal multilumen tube and stimulated small intestinal motility exogenously with a continuous intravenous infusion of the cholinergic agonist carbachol. Additionally, the ileum was perfused for 15-min intervals with either carbohydrates (total load: 18 g) or normal saline as volume control. Ileal carbohydrate perfusion inhibited the carbachol-stimulated motility pattern significantly (p < 0.001) and induced phase-III-like motor activity; ileal saline had no effect. These data suggest that a direct inhibition of cholinergic systems may be involved in the ileal inhibitory effects on proximal small intestinal motility.
ISSN:	0044-2771