Single dose comparison of torasemide and furosemide in patients with advanced renal failure

In a comparative study on the fluid and electrolyte excretion of 90 patients with chronic renal failure (serum creatinine greater than or equal to 3.0 mg/dl) 100 and 200 mg torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) vs. 100 and 200 mg furosemide were administered...

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Bibliographic Details
Published in:	Arzneimittel-Forschung Vol. 38; no. 1A; p. 200
Main Authors:	Klütsch, K, Grosswendt, J, Haecker, W
Format:	Journal Article
Language:	English
Published:	Germany 01-01-1988
Subjects:	Adult Aged Blood Pressure - drug effects Chlorides - blood Clinical Trials as Topic Creatinine - blood Diuretics - administration & dosage Diuretics - therapeutic use Double-Blind Method Female Furosemide - administration & dosage Furosemide - therapeutic use Heart Rate - drug effects Humans Kidney Failure, Chronic - drug therapy Male Middle Aged Potassium - blood Random Allocation Sodium - blood Sulfonamides - administration & dosage Sulfonamides - therapeutic use
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Summary:	In a comparative study on the fluid and electrolyte excretion of 90 patients with chronic renal failure (serum creatinine greater than or equal to 3.0 mg/dl) 100 and 200 mg torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) vs. 100 and 200 mg furosemide were administered intravenously. A long-acting salidiuretic effect was demonstrated for torasemide. Torasemide can thus be categorized as a high-ceiling, long-acting diuretic. Tolerance of both diuretics was comparable.
ISSN:	0004-4172