IgA nephritis in HIV-positive patients: a new HIV-associated nephropathy?

Four HIV-positive patients were shown to have IgA-associated nephritis on biopsy, including one with anaphylactoid purpura. Three were homosexuals, while the fourth acquired the infection from his mother. All had hematuria, a variable degree of proteinuria and renal disease with a benign course. Ser...

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Bibliographic Details
Published in:	Clinical nephrology Vol. 38; no. 2; p. 61
Main Authors:	Katz, A, Bargman, J M, Miller, D C, Guo, J W, Ghali, V S, Schoeneman, M J
Format:	Journal Article
Language:	English
Published:	Germany 01-08-1992
Subjects:	Adult AIDS-Associated Nephropathy - immunology AIDS-Associated Nephropathy - pathology Antigen-Antibody Complex - analysis Blotting, Western Child Glomerulonephritis, IGA - immunology Glomerulonephritis, IGA - pathology HIV Antibodies - analysis HIV Seropositivity - immunology Humans Immunoglobulin A - analysis Kidney - pathology Male Microscopy, Electron Purpura, Schoenlein-Henoch - immunology Rheumatoid Factor - analysis
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Summary:	Four HIV-positive patients were shown to have IgA-associated nephritis on biopsy, including one with anaphylactoid purpura. Three were homosexuals, while the fourth acquired the infection from his mother. All had hematuria, a variable degree of proteinuria and renal disease with a benign course. Serologic studies showed elevated levels of IgA as well as IgA immune complexes and rheumatoid factor. IgA antibodies to multiple HIV antigens were detected by Western blot. Pathologic studies showed tubuloreticular inclusions in endothelial cells and nuclear bodies in interstitial cells in all cases. HIV antigens were not detected in kidney biopsies by monoclonal antibodies nor was HIV viral genome demonstrated by in situ hybridization. The possibility that this represents a unique type of IgA-associated HIV nephropathy is discussed.
ISSN:	0301-0430