Acquired factor VIII inhibitor associated with chronic interferon-alpha therapy

Therapeutic use of interferon-alpha (IFN-alpha) has been associated with the development of a variety of autoimmune disorders. We describe a patient who received chronic treatment with IFN-alpha following autologous bone marrow transplantation for multiple myeloma. The patient developed an antibody...

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Bibliographic Details
Published in:	Journal of rheumatology Vol. 21; no. 2; p. 350
Main Authors:	Stricker, R B, Barlogie, B, Kiprov, D D
Format:	Journal Article
Language:	English
Published:	Canada 01-02-1994
Subjects:	Autoantibodies - blood Autoimmune Diseases - etiology Bone Marrow Transplantation Factor VIII - antagonists & inhibitors Factor VIII - immunology Humans Interferon-alpha - adverse effects Male Middle Aged Multiple Myeloma - surgery Multiple Myeloma - therapy
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Summary:	Therapeutic use of interferon-alpha (IFN-alpha) has been associated with the development of a variety of autoimmune disorders. We describe a patient who received chronic treatment with IFN-alpha following autologous bone marrow transplantation for multiple myeloma. The patient developed an antibody inhibitor directed against factor VIII coagulant protein (FVIIIC) leading to a fatal hemorrhagic diathesis. The association between IFN-alpha therapy and autoimmune complications deserves wider recognition and further study.
ISSN:	0315-162X