Count and phagocytic activity of leukocytes in rats with experimental depressive syndrome caused by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

• Published in: Bulletin of experimental biology and medicine Vol. 130; no. 11; p. 1041
• Main Authors: Krupina, N A, Davydova, T V, Fomina, V G, Kryzhanovskii, G N, Orlova, I N
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01-11-2000
• Subjects: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology; Animals; Depressive Disorder - blood; Depressive Disorder - chemically induced; Depressive Disorder - immunology; Dopamine Agents - administration & dosage; Dopamine Agents - pharmacology; Fish; Leukocyte Count; Leukocytes - drug effects; Leukocytes - immunology; Male; Neutrophils - drug effects; Neutrophils - immunology; Phagocytosis - drug effects; Rats; Rats, Wistar
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1023/A:1002823129397

Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated with changes in the absolute neutrophil and monocyte counts.