B cell surface marker analysis of synovial fluid cells in a patient with monoarthritis and chronic lymphocytic leukemia

We describe a women with clinically quiescent chronic lymphocytic leukemia who developed monoarthritis consistent with her known diagnosis of osteoarthritis. Because of the concurrent chronic leukemia, we were concerned with the possibility of leukemic arthritis. Immunofluorescence of synovial fluid...

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Bibliographic Details
Published in:	Journal of rheumatology Vol. 19; no. 3; p. 481
Main Authors:	Fort, J G, Fernandez, C, Jacobs, S R, Abruzzo, J L
Format:	Journal Article
Language:	English
Published:	Canada 01-03-1992
Subjects:	Aged Antigens, Surface - analysis Arthritis - diagnosis Arthritis - etiology Arthritis - immunology B-Lymphocytes - immunology Female Humans Knee Joint - diagnostic imaging Knee Joint - pathology Leukemia, Lymphocytic, Chronic, B-Cell - complications Radiography Synovial Fluid - cytology Synovitis - diagnosis Synovitis - etiology Synovitis - immunology
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Summary:	We describe a women with clinically quiescent chronic lymphocytic leukemia who developed monoarthritis consistent with her known diagnosis of osteoarthritis. Because of the concurrent chronic leukemia, we were concerned with the possibility of leukemic arthritis. Immunofluorescence of synovial fluid cells demonstrated an increase in B cells that failed to demonstrate monoclonality as determined by light chain class expression. However, biopsy of synovial tissue revealed leukemic infiltration. Local radiation therapy resolved the monoarthritis.
ISSN:	0315-162X