Antineoplastic effect of the xanthine derivative Trental

The xanthine derivative, Trental (pentoxifylline) was found to inhibit several human leukemic and lymphoma cell lines in tissue cultures. Optimal concentrations were less inhibitory for a normal B-lymphocyte cell line then for the neoplastic cell lines. In fact, small concentrations stimulated DNA s...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of medicine Vol. 15; no. 5-6; p. 355
Main Authors:	Biddle, W, Ambrus, C M, Gastpar, H, Ambrus, J L
Format:	Journal Article
Language:	English
Published:	United States 1984
Subjects:	B-Lymphocytes - drug effects B-Lymphocytes - metabolism Burkitt Lymphoma - drug therapy Burkitt Lymphoma - metabolism Burkitt Lymphoma - therapy Cell Line Combined Modality Therapy DNA - biosynthesis Humans Interferon Type I - therapeutic use Leukemia - drug therapy Leukemia - metabolism Leukemia - therapy Leukemia, Lymphoid - therapy Leukemia, Myeloid, Acute - therapy Pentoxifylline - administration & dosage Pentoxifylline - pharmacology Pentoxifylline - therapeutic use Theobromine - analogs & derivatives
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The xanthine derivative, Trental (pentoxifylline) was found to inhibit several human leukemic and lymphoma cell lines in tissue cultures. Optimal concentrations were less inhibitory for a normal B-lymphocyte cell line then for the neoplastic cell lines. In fact, small concentrations stimulated DNA synthesis in the normal cell line. Trental and beta-interferon appeared to be additive synergists at certain dosages. Possible mechanisms are discussed.
ISSN:	0025-7850