Chondroid lipoma : A newly described lesion that may be mistaken for malignancy

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 81; no. 5; pp. 586 - 589
• Main Authors: GOMEZ-ORTEGA, J. M, RODILLA, I. G, BASCO LOPEZ DE LERMA, J. M
• Format: Journal Article
• Language: English
• Published: St. Louis, MO Elsevier 01-05-1996
• Subjects: Adipose Tissue - pathology; Adult; Biological and medical sciences; Collagen - analysis; Dentistry; Diagnosis, Differential; Eosinophils - pathology; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Humans; Immunohistochemistry; Lipoma - chemistry; Lipoma - pathology; Male; Medical sciences; Otorhinolaryngology. Stomatology; Phosphopyruvate Hydratase - analysis; S100 Proteins - analysis; Submandibular Gland Neoplasms - chemistry; Submandibular Gland Neoplasms - pathology; Tumors; Vimentin - analysis; Human; Case study; Pathology; Maxillary; ENT disease; Adult; Male; Adipose tissue disorders; Benign neoplasm; Malignant tumor; Lipoma; Differential diagnostic
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/S1079-2104(96)80053-9

A case of chondroid lipoma located in the submandibular region of a 21-year-old man is presented. On macroscopic evaluation the tumor was lobulated and quite yellow. Microscopic examination showed that this tumor was composed of mature adipose tissue and eosinophilic cells. The eosinophilic cells displayed single or multiple vacuoles and resembled lipoblast or hibernoma-like cells. These were set in a myxoid or chondromyxoid stroma. Most cells reacted with antibodies directed against vimentin and neuron-specific enolase. Focal weak positivity for S-100 protein was noted. Principal considerations in the histopathologic differential diagnosis included hibernoma, myxoid liposarcoma, and extraskeletal myxoid chondrosarcoma (chordoid sarcoma).