Different effects of interleukin-1 on reactivity of arterial vessels isolated from various vascular beds in the rabbit

• Published in: Circulatory shock Vol. 40; no. 2; p. 139
• Main Authors: Robert, R, Chapelain, B, Néliat, G
• Format: Journal Article
• Language: English
• Published: United States 01-06-1993
• Subjects: Animals; Aorta - drug effects; Aorta - physiology; Arteries - drug effects; Arteries - physiology; Carotid Arteries - drug effects; Carotid Arteries - physiology; Femoral Artery - drug effects; Femoral Artery - physiology; Interleukin-1 - pharmacology; Male; Muscle Contraction - drug effects; Norepinephrine - pharmacology; Pulmonary Artery - drug effects; Pulmonary Artery - physiology; Rabbits; Renal Artery - drug effects; Renal Artery - physiology
• ISSN: 0092-6213

During septic shock, arterial smooth muscle is thought to be hyporeactive to vasoconstrictors. This hyporeactivity, however, seems to be different from one vascular bed to another. Interleukin-1 (IL-1), which is released during septic shock, might play a role in the different regional vascular responses to norepinephrine. Thus, the aim of the present study was to examine in vitro the effect of IL-1 on the response to norepinephrine of arteries isolated from different territories in the rabbit. Three types of responses were identified: IL-1 decreased NE-induced contraction by 54% in aorta, 42% in carotid artery, 54% in pulmonary artery, and 18% in renal artery; and IL-1 was devoid of significant effect in hepatic and mesenteric arteries; and IL-1 increased NE-induced contraction by 25% in femoral arteries. In conclusion, IL-1 might contribute to the regional blood flow abnormalities during septic shock.