Inverse relationship of serum LDL cholesterol and the LDL/HDL cholesterol ratio to liver microsomal enzyme induction in man

The association of serum LDL cholesterol and the LDL/HDL cholesterol ratio, the major positive risk factors of coronary heart disease, to hepatic microsomal enzyme induction assessed by liver cytochrome P-450, was investigated in 18 subjects who were treated with inducing anticonvulsants. In subject...

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Bibliographic Details
Published in:	Research communications in chemical pathology and pharmacology Vol. 42; no. 1; p. 173
Main Authors:	Luoma, P V, Sotaniemi, E A, Pelkonen, R O
Format:	Journal Article
Language:	English
Published:	United States 01-10-1983
Subjects:	Adult Anticonvulsants - pharmacology Cholesterol - blood Cholesterol, HDL Cholesterol, LDL Coronary Disease - etiology Cytochrome P-450 Enzyme System - biosynthesis Enzyme Induction - drug effects Humans Lipoproteins, HDL - blood Lipoproteins, LDL - blood Microsomes, Liver - enzymology Middle Aged
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Summary:	The association of serum LDL cholesterol and the LDL/HDL cholesterol ratio, the major positive risk factors of coronary heart disease, to hepatic microsomal enzyme induction assessed by liver cytochrome P-450, was investigated in 18 subjects who were treated with inducing anticonvulsants. In subjects with normal liver histology, LDL cholesterol and the LDL/HDL cholesterol ratio were inversely proportional to the magnitude of induction. Strong induction was associated with a low LDL cholesterol level. The serum cholesterol distribution profile and the low LDL/HDL cholesterol ratio associated with induction are characteristic of low risk of coronary heart disease. The present findings support studies showing a positive association between HDL cholesterol and induction and suggesting a new therapeutic approach to atherosclerotic vascular disease.
ISSN:	0034-5164