Comparison of the in vitro effects of several cephalosporins on the oxidative burst of human phagocytes

The metabolic activity (oxygen radical formation) of human phagocytes was not substantially affected by the tested cephalosporins. Therapeutic concentrations caused only a mild suppression or immunopotentiation in some cases or there were no effects altogether.

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Bibliographic Details
Published in:	Folia microbiologica Vol. 38; no. 3; pp. 253 - 258
Main Authors:	KUBICKOVA, D, BENES, L, LOJEK, A, CIZ, M, PILLICH, J
Format:	Journal Article
Language:	English
Published:	Praha Academia 01-01-1993
Subjects:	Biological and medical sciences Cefotaxime - pharmacology Cefsulodin - pharmacology Ceftazidime - pharmacology Ceftriaxone - pharmacology Cell metabolism, cell oxidation Cell physiology Cephalosporins - pharmacology Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Kinetics Molecular and cellular biology Neutrophils - drug effects Neutrophils - metabolism Oxidation-Reduction Phagocytes - drug effects Phagocytes - metabolism Respiratory Burst - drug effects Characterization Human Cephalosporin derivatives Oxidation potential Metabolism In vitro Phagocyte
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Description
Summary:	The metabolic activity (oxygen radical formation) of human phagocytes was not substantially affected by the tested cephalosporins. Therapeutic concentrations caused only a mild suppression or immunopotentiation in some cases or there were no effects altogether.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02814387