Antidepressant activity of aspartic acid derivatives

Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant activity after single injection in the forced swimming and tail suspension tests. Antidepressan...

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 131; no. 4; pp. 342 - 345
Main Authors:	Petrov, V I, Sergeev, V S, Onishchenko, N V, Piotrovskii, L B
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-04-2001
Subjects:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Aspartic Acid - therapeutic use Disease Models, Animal Motor Activity - drug effects Rats Swimming
Online Access:	Get full text
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Summary:	Antidepressant activity of N-phenyl(benzyl)amino derivatives of aspartic acid was studied on various experimental models of depression. IEM-1770 (30 mg/kg) and IEM-1944 (20 mg/kg) exhibited antidepressant activity after single injection in the forced swimming and tail suspension tests. Antidepressant effect of 14-day administration of these compounds and reference drugs maprotiline (10 mg/kg) and citalopram (10 mg/kg) was confirmed on the model of learned helplessness.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1017948001979