Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency

Systemic oral administration of NT-0409, a new synthetic agonist of AMPA subtype glutamate receptor, to rats with chronic partial AF64A-induced deprivation of cholinergic functions improved their learning in a Morris water maze. NT-0409 is close to memantine by the effect on learning and, in contras...

Full description

Saved in:

Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 135; no. 1; p. 48
Main Authors:	Lermontova, N N, Mukhina, T V, Van'kin, G I, Serkova, T P, Bachurin, S O
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-01-2003
Subjects:	Alzheimer Disease - chemically induced Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Animals Aziridines - toxicity Brain - drug effects Brain - pathology Choline - analogs & derivatives Choline - toxicity Excitatory Amino Acid Agonists - pharmacology Male Maze Learning - drug effects Memantine - pharmacology Memory - drug effects Rats Rats, Wistar Receptors, AMPA - agonists
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Systemic oral administration of NT-0409, a new synthetic agonist of AMPA subtype glutamate receptor, to rats with chronic partial AF64A-induced deprivation of cholinergic functions improved their learning in a Morris water maze. NT-0409 is close to memantine by the effect on learning and, in contrast to cholinomimetic arisept, ensures longer retention of the developed habit.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1023493828612