Calcium Channels in Vascular Smooth Muscle

Calcium (Ca ) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca concentration ([Ca ] ) is crucial for proper physiological VSM function. Studies over the last several decades have revealed...

Full description

Saved in:

Bibliographic Details
Published in:	Advances in pharmacology (1990) Vol. 78; p. 49
Main Authors:	Ghosh, D, Syed, A U, Prada, M P, Nystoriak, M A, Santana, L F, Nieves-Cintrón, M, Navedo, M F
Format:	Journal Article
Language:	English
Published:	United States 2017
Subjects:	Animals Calcium - metabolism Calcium Channels - metabolism Calcium Signaling - physiology Humans Muscle, Smooth, Vascular - metabolism Ion channels Myogenic tone Sarcoplasmic reticulum Arteries Ca(2+) signaling Contraction
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Calcium (Ca ) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca concentration ([Ca ] ) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca -permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca ] . In this review, we discuss the major Ca -permeable channels expressed in VSM and their contribution to vascular physiology and pathology.
ISSN:	1557-8925
DOI:	10.1016/bs.apha.2016.08.002